importance of subtype selectivity for endothelin receptor antagonists in the human vasculature
Tài liệu Translational Vascular Medicine docx
... Rossi 10 Importance of Subtype Selectivity for Endothelin Receptor Antagonists in the Human Vasculature 151 Janet J Maguire and Anthony P Davenport 11 Non-Pharmacological Treatment of Peripheral ... Smith Building, School of Biomedicine, Faculty of Medical & Human Sciences, University of Manchester, Manchester, UK Shalini Jadeja, Medical and Developmental Genetics, MRC Human Genetics Unit, ... inhibition (for example, because of loss of additional non-catalytic effects of the enzyme protein) It is worth noting, however, that supplementation of a certain brand of Canadian beer with cobalt...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... selected subsets of T cells [2,18,19] Earlier studies on human CD1d expression showed that this unconventional MHC class I molecule localizes in the cytoplasm of human epithelial cells of the gastrointestinal ... examined whether iron loading of the liver epithelial cell line HepG2 influenced the expression of immune regulatory molecules known to function as ligands of selected subsets of T cells, such as MHC ... expression of the transferrin receptor, ferritin and storage iron in HepG2 cells grown in media supplemented with 100 lm of ferric citrate (iron-rich media), the most common form of nontransferrin...
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt
... spread of the tolerogenic microenvironment To determine whether HLA-G 4234 receptors are also capable of responding pressive stimulus under oxidative stress, study aimed to investigate the effect of ... related to the presence of exposed Tyr residues [19–21] To our knowledge, this is the first report of a post-translational modification of the ILT2 protein The other member of the ILT family, LILRA4, ... glucocorticoid receptor, where nitration leads to an increase in binding capacity [25] Identification of nitration site in the extracellular domain of ILT2 In the extracellular domain of ILT2, there...
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Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum potx
... rate of FP degradation was [FP]-dependent with an apparent Km of 71 lm and a Vmax of 2.4 nmolÆmin)1 (Fig 1D) The rate in the presence of rPf1-Cys-Prx was also [FP]dependent with an apparent Km of ... 7.4 most of the added FEBS Journal 272 (2005) 1784–1791 ª 2005 FEBS 1785 Roles of Prx in heme degradation of P falciparum S.-i Kawazu et al A Fig GPx activity of Pf1-Cys-Prx GPx activity of rPf1-Cys-Prx ... formation of the membraneassociated FP Further studies of such functions of Prx will clarify the mechanism underlying detoxification of FP by P falciparum and may facilitate development of alternative...
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Báo cáo khoa học: "AMBIGUITY RESOLUTION IN THE HUMAN SYNTACTIC PARSER: AN EXPERIMENTAL STUDY" ppt
... descriptions of the overall operations of the human system: ISA and IPA-with-momentary-parallelism Second, the duration of this delay is variable, and therefore any model in which the point of resolution ... further type of model is characterized by Immediate Parallel Analysis (IPA), in which a l l of the possib~ analyses of an ambiguity are b u i l t as soon as the ambiguous portion of the string ... embedded among a large number of f i l l e r items whose presentation stopped at a wide variety of points Many of these f i l l e r s also contained ungrammaticalities, of various sorts and in various...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
... intracellular concentration of Fru is about two orders of magnitude below the apparent Km of 40 mm A physiological role of AfM2DH in the utilization of intracellular Man-ol via reversal of path in Scheme ... to binding of proteins of the human host The high specicity of AfM1PDH for reactions with phosphorylated substrates could be a feature of recognition to be exploited in the design of selective ... pathogenic potential of a mannitol mutant of Cryptococcus neoformans Microbiology 142(Pt 4), 937943 Chaturvedi V, Wong B & Newman SL (1996) Oxidative killing of Cryptococcus neoformans by human neutrophils...
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Báo cáo khoa học: A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP docx
... antibodies The integrity of the substrate-binding domain of CtBP2 is required for recognition of the GLDLSKK motif Crystal structure analyses of the substrate-binding domain of CtBP1 have highlighted ... with 250 ng of the pG5-luc reporter (schematically drawn), 50 ng of the pSG5-lacZ construct as a control of transfection efficiency, 50 ng of the indicated Gal4 construct and 150 ng of the VP16 ... potential of full-length HIC1 U2OS cells were transfected with 225 ng of the indicated expression vector, 225 ng of the reporter 5xHiRE-luc plasmid and 50 ng of the pSG5-lacZ construct as control of...
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Báo cáo khoa học: Human-blind probes and primers for dengue virus identification Exhaustive analysis of subsequences present in the human and 83 dengue genome sequences doc
... Number of n-mers absent from the human genome 408 Table S4 Number of human- blind n-mers, one, two, three or four changes away, present in each dengue genome Table S5 Number of unique human- blind ... different sizes of n and number of changes away from the nearest human sequence Also listed is the average number of 22-mers present in an individual genome and absent from the human sequence ... increases, the number of common n-mers decreases Second, because the number of human- blind sequences in general is smaller for small n-mer sizes (no human- blind n-mers for n < 11 and no human- blind n-mers...
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Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf
... accordance with those of RT–PCR (Fig 3B) DR4, DR5 and DcR-2 are receptors for TRAIL and their genes are downstream targets of p53 [34–37] The upregulation of TRAIL death receptors, especially ... significantly decreased in the presence of zVADFMK However, the decrease of Bax in the presence of zVAD-FMK was not as marked as that of cytochrome c Fig The enhanced cleavage of caspases by combined treatment ... concentration of · 106 cellsÆmL)1 One-hundred microlitres of this resuspended solution (1 · 105 cells) was transferred to a 5-mL culture tube After incubation with lL of Annexin V–FITC and 10 lL of phosphatidylinositol...
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Báo cáo khoa học: Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase pdf
... activity of E78IIQ matched that of wild-type, while the activity of the E78IIA mutant was lowered to about 50% (Table 1) Given the lower activity of the E78IIA mutant, the kinetics of reduction of ... absence of NO acting as a trapping ligand for reduced heme a3 [27] Proton-pumping activity Fig Kinetics of heme a3 reduction of wild-type and mutant P denitrificans oxidase Degassed samples of the ... the absorbance change of the pH-sensitive dye phenol red [29] Experiments in the absence and presence of the uncoupler CCCP gave a H+ ⁄ e– ratio of 0.9 very similar to that of the wild-type enzyme...
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Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain" ppt
... of the slope of the linear part of the Logan plot, curvature of the plot throughout the duration of scanning impairs the estimation of the binding potential (see Figure 3) Since the binding of ... is the only radioligand of a popular antidepressant drug that is suitable for PET imaging of the brain in humans We realize, of course, that mirtazapine affects multiple receptor systems, including ... radiopharmaceutical identity and was expressed as a percentage of the total of all radioanalytes recovered by HPLC Seven radiochemical fractionations of extracts of plasma samples were measured at 1, 2.5, 5,...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF ... proliferation of Matsumoto et al Journal of Orthopaedic Surgery and Research 2010, 5:85 http://www.josr-online.com/content/5/1/85 Page of Figure Expression of VEGF and the VEGF receptors in giant ... activation of matrix metalloproteinase and invasion of human osteosatcoma cells Jpn J Cancer Res 2001, 92:429-438 O’Connell JX, Wehrli BM, Nielsen GP, Rosenberg AE: Giant cell tumors of soft tissue:...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing OCs (data not shown) To determine the immunolocalization of VEGF ... proliferation of Matsumoto et al Journal of Orthopaedic Surgery and Research 2010, 5:85 http://www.josr-online.com/content/5/1/85 Page of Figure Expression of VEGF and the VEGF receptors in giant ... activation of matrix metalloproteinase and invasion of human osteosatcoma cells Jpn J Cancer Res 2001, 92:429-438 O’Connell JX, Wehrli BM, Nielsen GP, Rosenberg AE: Giant cell tumors of soft tissue:...
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Báo cáo hóa học: " Research Article Robust Object Categorization and Segmentation Motivated by Visual Contexts in the Human Visual System" docx
... analysis Top-down synthesis Figure 8: The overall flow of object categorization of human visual system Region of interest For 2D object: region of interest (object center, scale) Figure/ground mask ... several biological findings of human visual systems for the large intraclass variation and background clutter issues The next section summarizes the mechanisms of the human visual system for visual ... Prob of feature position 1 0.8 0.4 0.2 (a) 0.5 0.3 0.4 0.2 Prob of feature position 0.3 0.2 0.1 0.2 0.4 p(σ | F) 0.6 0.4 0.8 0.6 Prob of scale 0.1 (b) Figure 17: Probability distribution of a...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... bFGF, FGF -Receptor 2, IL-13, IL-5, eotaxin, and CCR3 (in order of highest to lowest extent of increased transcript expression) Interestingly, upon examination of transcript expression of signaling ... expression of ERK in the PBMC of EoE subjects, and it is possible that, together with eotaxin, FGF enhances activation of eosinophils in EoE specifically Page of The increased global expression of bFGF ... the investigation of the local expression bFGF of the esophageal biopsies of the subjects Our data show that FGF, as assessed by IHC of local tissue and bFGF assessed by QT-PCR of PBMC, are upregulated...
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Báo cáo y học: "Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium" pps
... chemokine receptors [11] CC receptors (CCR) bind members of the class of chemokines with two adjacent cysteine (C) residues near the NH2-terminus (CC; e.g CCL2, CCL3 and CCL5) and CXC receptors ... is known about the expression of chemokine receptors on phagocytes in the human RA synovium One recent study has shown the protein expression of several chemokine receptors on monocytes/ macrophages ... of the corresponding CC chemokine receptors on these cells This is in agreement with other studies showing lack of CCL2 binding to blood neutrophils and general lack of chemotactic response of...
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Báo cáo y học: " NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitid" pot
... (24 out of 28) of the genes longer than kbp were hit 5.7 times on average, 62% (58 out of 94) of the genes between and kbp long were hit 3.7 times on average, while only 21% (14 out of 66) of the ... pentose-phosphate and Entner-Doudoroff pathways) and may be capable of de novo synthesis of all 20 amino acids Inspection of the non-core Table Summary of the (re)annotation effort of eight Neisseria genomes ... example, through completion of the collection of mutants (either through gene-by-gene or systematic targeted mutagenesis of the missed genes), further improvement of the accuracy of the annotation by...
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Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot
... difference between the set of spliced exons and that of highly expressed exons Calculating the strength of exon splice sites The sum of the scores of the splice sites of each internal exon was ... About 80% of the human genome was known to be covered by high-throughput sequencing [33] The mappable portion of the human genome that harbors open chromatin was compared with the fraction of CGIs ... the other hand, the functional importance of coding exons might restrict the loss of these marks that ensure exon inclusion into mature transcripts The main- tenance of these marks in coding exons...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25